Sunday, November 7, 2010

Crossroads of Pain and Addiction

Crossroads of Pain and Addiction - Bailey - 2010 - Pain Medicine - Wiley Online LibrarySkip to Main Content

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DOI: 10.1111/j.1526-4637.2010.00982.x

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How to CiteBailey, J. A., Hurley, R. W. and Gold, M. S. , Crossroads of Pain and Addiction. Pain Medicine, no. doi: 10.1111/j.1526-4637.2010.00982.x

Author Information1

Pain and Addiction Medicine in the Division of Addiction Medicine, Department of Psychiatry, University of Florida's Springhill Health Center

2

Division of Pain, Department of Anesthesiology, University of Florida

3

Department of Psychiatry, McKnight Brain Institute, Gainesville, FL, USA

*Correspondence: John A. Bailey MD,

*Correspondence: John A. Bailey, MD, Springhill Health Center, 8491 NW 39th Ave., Gainesville, FL 32606, USA. Tel: 352?265?5404; Fax: 352?376?6270; E?mail: baileyjo@ufl.edu.

Publication HistoryArticle first published online: 28 OCT 2010 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (203K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Get PDF (203K) Keywords:Pain Training Programs;Drug Abuse;Addiction;Chronic PainAbstract

Background.? Despite the fact that chronic pain and addiction often coexist, few pain training programs offer significant experiential and didactic training in drug abuse and addiction. Similarly, addiction medicine programs often offer little training in pain management. What follows is a review of the intersection between these two specialties from the perspective of clinicians that practice both.

Objective.? The objective of this study was to review the historical backdrop, terminology, vulnerability, and neurobiology of addiction; explore the effects of drug, delivery system, timing, and environment on drug self?administration; and review strategies used in managing patients with coexisting addiction and chronic pain.

Setting.? The University of Florida has training programs in both pain management and addiction medicine. The collaboration of these two subspecialties has led to the development of a successful pain management clinic that manages difficult patients based on the strategies that are discussed.

Conclusions.? It is possible to successfully manage patients with coexisting chronic pain and addictive disorders. Addiction medicine and pain management training programs should offer didactic and experiential training in both subspecialties.

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Copyright ? 1999-2010 John Wiley & Sons, Inc. All Rights Reserved.

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Mirador Gets FDA OK for Two Needle Pressure Devices

Filed under: Anesthesiology , Critical Care , Emergency Medicine , Medicine , Pediatrics , Surgery


Here's an interesting simple technology that might come handy to anesthesiologists and others who tend to do lots of central lines. Making sure that you are not in a carotid (or subclavian or femoral arteries, etc) is not always as simple as many think. Sure, you can do a blood color comparison. You can also connect a vertical column, and see how far the blood will rise. But why to do these maneuvers, if you can have something at the end of a finder needle that does not add steps to your procedure? Meet Mirador Biomedical of Seattle, Washington that has just received FDA's 510(k) clearance for its Compass Vascular Access pressure measurement device, as well as a similarly designed Compass Lumbar Puncture pressure monitor.

From the Compass Vascular Access product page:

Focus on the Procedural Site

View your hands, the patient and the pressure without additional cabling, operators or connections

Integrate Seamlessly with Needles and Syringes
Easily incorporated into the Seldinger technique for inserting catheters

Eliminate “Blind” Guidewire Insertion
The port allows insertion of the guidewire while monitoring the pressure

From Compass Lumbar Puncture product page:

Indication of CSF Entrance:

Entrance into the target space is indicated by a pressure increase.

Seamless Integration with LP Needles:
The CompassTM LP connects to standard Lumbar puncture needles.

Immediate and Continuous Measurement of Opening Pressure:
View the pressure continuously without additional cabling, operators or connections.

Press release: Mirador Biomedical, developing the innovative Compass? family of disposable medical devices, announced FDA 510(k) clearance of its two leading products... (.pdf)

Product page: Compass pressure measurement devices...



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Emergency transfusion for acute severe anemia: a calculated risk.

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Preoperative Glucose Levels Predict 1-Year Mortality After Surgery

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Reversible lactic acidosis and electrocardiographic changes in a neurosurgical patient during propofol anesthesia.

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Saturday, November 6, 2010

Local Anesthetics Are Effective for Neuropathic Pain

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Nefopam pharmacokinetics in patients with end-stage renal disease.

R?animation Chirurgicale Polyvalente, CHU de Poitiers, 86021 Poitiers Cedex, France. o.mimoz@chu-poitiers.f.

BACKGROUND: Treatment of intense postoperative pain in patients with end-stage renal disease (ESRD) is a recurrent problem for anesthesiologists because of the risk of accumulation of numerous molecules and their metabolites. Nefopam is a potent analgesic metabolized by the liver and weakly eliminated intact in urine that may offer advantages for use in patients with ESRD because it lacks respiratory-depressive effects. However, the effects of renal failure on nefopam disposition have never been investigated.

METHODS: We studied 12 ESRD patients (creatinine clearance <20 mL/min, mean age 57 ? 13 years) having surgery under general anesthesia to create or repair an arteriovenous fistula. Postoperatively, after complete recovery from anesthesia, each patient received a single 20-mg dose of nefopam IV over 30 minutes. Nefopam and desmethyl-nefopam concentrations in plasma samples obtained over 48 hours were determined by liquid chromatography-tandem mass spectrometry. The pharmacokinetic parameter values obtained were compared with those of 12 healthy 50- to 60-year-old volunteers who also received a single 20-mg nefopam infusion over 30 minutes using a population pharmacokinetic approach.

RESULTS: Healthy volunteers and ESRD patients had comparable demographic characteristics. In comparison with those volunteers, ESRD patients had a lower volume of central compartment (115 and 53 L vs. 264 L for patients not yet hemodialyzed and on chronic hemodialysis, respectively; P < 0.001) and lower mean nefopam clearance (37.0 and 27.3 L/h vs. 52.9 L/h, P < 0.001), resulting in higher mean nefopam peak concentration (121 and 223 ng/mL vs. 61 ng/mL, P < 0.001).

CONCLUSIONS: Nefopam distribution and elimination are altered in patients with ESRD, resulting in heightened exposure. To avoid too-high concentration peaks, it is suggested that the daily nefopam dose be reduced by 50%.

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Dexmedetomidine Infusion for the Management of Opioid‐Induced Hyperalgesia

Dexmedetomidine Infusion for the Management of Opioid?Induced Hyperalgesia - Belgrade - 2010 - Pain Medicine - Wiley Online LibrarySkip to Main Content

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PUBLICATIONSBROWSE BY SUBJECTRESOURCESABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED ?FORGOTTEN PASSWORD ?INSTITUTIONAL LOGIN > JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy JOURNAL MENU Journal Home FIND ISSUES Current IssueAll IssuesVirtual Issues FIND ARTICLES Early View GET ACCESS Subscribe / Renew FOR CONTRIBUTORS Author GuidelinesSubmit an Article ABOUT THIS JOURNAL Society InformationNewsOverviewEditorial BoardPermissionsAdvertiseContact SPECIAL FEATURES Professional OpportunitiesPainPoints Blog Dexmedetomidine Infusion for the Management of Opioid?Induced HyperalgesiaMiles Belgrade MD, Sara Hall MS, ACNS?BC, RN?BCArticle first published online: 28 OCT 2010

DOI: 10.1111/j.1526-4637.2010.00973.x

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How to CiteBelgrade, M. and Hall, S. , Dexmedetomidine Infusion for the Management of Opioid?Induced Hyperalgesia. Pain Medicine, no. doi: 10.1111/j.1526-4637.2010.00973.x

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Fairview Pain Management Center, University of Minnesota Medical Center, Minneapolis, Minnesota, USA

*Correspondence: Miles Belgrade, MD, 606 24th Ave. S., Suite 600, Minneapolis, MN 55454, USA.? Tel: 612?273?9925; Fax: 612?273?9945;? E?mail: mbelgra1@fairview.org.

Publication HistoryArticle first published online: 28 OCT 2010 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (521K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Get PDF (521K) Keywords:Opioid?Induced Hyperalgesia;Dexmedetomidine;Alpha?2 Adrenergic Agonists;Opioid Withdrawal;Opioid ToleranceAbstract

Objective.? Understanding the actions of opioids now encompasses pronociceptive as well as antinociceptive mechanisms. Opioid?induced hyperalgesia (OIH) refers to increased pain sensitivity due to high?dose or prolonged opioid exposure. It has become more important as patients with pain remain on opioids at higher doses for longer periods of time. One setting that highlights the dilemma of OIH is in the opioid?tolerant patient who is hospitalized for painful medical conditions or procedures and is unable to achieve adequate analgesia despite escalating opioid doses. This patient population often requires agents that act synergistically with opioids through different mechanisms to achieve analgesia. Dexmedetomidine is an alpha?2 adrenergic agonist that has been shown to synergize with opioids.

Setting.? Tertiary care hospital.

Design.? Case series.

Method.? Eleven hospitalized patients with OIH received dexmedetomidine to improve pain control and to lower opioid doses while avoiding opioid withdrawal.

Results.? A total of 64% (7/11) had substantial reductions in their baseline opioid doses at the time of discharge.

Conclusions.? The cases presented provide support for the clinical utility of alpha?2 agonists during opioid dose reduction in patients with OIH as well suggesting that they may contribute to the recovery of normal nociceptive and antinociceptive responses.

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Why Is Urine Drug Testing Not Used More Often in Practice?

Why Is Urine Drug Testing Not Used More Often in Practice? - Bair - 2010 - Pain Practice - Wiley Online LibrarySkip to Main Content

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PUBLICATIONSBROWSE BY SUBJECTRESOURCESABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED ?FORGOTTEN PASSWORD ?INSTITUTIONAL LOGIN > JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy JOURNAL MENU Journal Home FIND ISSUES Current IssueAll Issues FIND ARTICLES Early View GET ACCESS Subscribe / Renew FOR CONTRIBUTORS Author GuidelinesSubmit an Article ABOUT THIS JOURNAL Society InformationNewsOverviewEditorial BoardPermissionsAdvertiseContact SPECIAL FEATURES Professional Opportunities Why Is Urine Drug Testing Not Used More Often in Practice?Matthew J. Bair MD, MS, Erin E. Krebs MD, MPHArticle first published online: 29 OCT 2010

DOI: 10.1111/j.1533-2500.2010.00425.x

? 2010 The Authors. Pain Practice ? 2010 World Institute of Pain

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Pain PracticePain PracticeVolume 10, Issue 6, pages 493–496, November/December 2010

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How to CiteBair, M. J. and Krebs, E. E. (2010), Why Is Urine Drug Testing Not Used More Often in Practice?. Pain Practice, 10: 493–496. doi: 10.1111/j.1533-2500.2010.00425.x

Author Information

Roudebush VA Center of Excellence on Implementing Evidence?Based Practice; Department of Medicine, Indiana University School of Medicine; Regenstrief Institute, Inc., Indianapolis, Indiana, U.S.A.

*Correspondence: Matthew J. Bair, MD, MS, Roudebush VA Medical Center (11?H), 1481 West 10th Street, Indianapolis, IN 46202, U.S.A. E?mail: mbair@iupui.edu; matthew.bair@va.gov.

Publication HistoryIssue published online: 29 OCT 2010Article first published online: 29 OCT 2010 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (51K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Get PDF (51K) First page of articleFirst page of Why Is Urine Drug Testing Not Used More Often in Practice? View Full Article (HTML) Get PDF (51K) More content like this Find more content: like this article Find more content written by:Matthew J. BairErin E. KrebsAll Authors ABOUT USHELPCONTACT USAGENTSADVERTISERSMEDIAPRIVACYTERMS & CONDITIONSSITE MAP

Copyright ? 1999-2010 John Wiley & Sons, Inc. All Rights Reserved.

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Feasibility and precision of cerebral blood flow and cerebrovascular reactivity MRI measurements using a computer‐controlled gas delivery system in an anesthetised juvenile animal model

Analgesia with noninvasive electrical cortical stimulation: challenges to find optimal parameters of stimulation.

Anesth Analg. 2010 Nov;111(5):1083-5.

Fregni F.

Comment on: PMID: 20971956 [PubMed - in process]Free Article

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Friday, November 5, 2010

Phosphate‐containing dialysis solution prevents hypophosphatemia during continuous renal replacement therapy

Phosphate?containing dialysis solution prevents hypophosphatemia during continuous renal replacement therapy - BROMAN - 2010 - Acta Anaesthesiologica Scandinavica - Wiley Online LibrarySkip to Main Content

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PUBLICATIONSBROWSE BY SUBJECTRESOURCESABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED ?FORGOTTEN PASSWORD ?INSTITUTIONAL LOGIN > JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy JOURNAL MENU Journal Home FIND ISSUES Current IssueAll Issues FIND ARTICLES Early ViewMost AccessedMost Cited GET ACCESS Subscribe / Renew FOR CONTRIBUTORS Author GuidelinesSubmit an Article ABOUT THIS JOURNAL Society InformationNewsOverviewEditorial BoardPermissionsAdvertiseContact SPECIAL FEATURES Free ContentVirtual Issue: Clinical Practice GuidelinesEditorial PolicyWiley's Anesthesia Collection Phosphate?containing dialysis solution prevents hypophosphatemia during continuous renal replacement therapyM. BROMAN1, O. CARLSSON2, H. FRIBERG1, A. WIESLANDER2, G. GODALY2Article first published online: 29 OCT 2010

DOI: 10.1111/j.1399-6576.2010.02338.x

? 2010 The Authors. Journal compilation ? 2010 The Acta Anaesthesiologica Scandinavica Foundation

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Acta Anaesthesiologica ScandinavicaActa Anaesthesiologica ScandinavicaEarly View (Articles online in advance of print)

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How to CiteBROMAN, M., CARLSSON, O., FRIBERG, H., WIESLANDER, A. and GODALY, G. , Phosphate?containing dialysis solution prevents hypophosphatemia during continuous renal replacement therapy. Acta Anaesthesiologica Scandinavica, no. doi: 10.1111/j.1399-6576.2010.02338.x

Author Information1

Department of Anaesthesiology and Intensive Care, Lund University Hospital, Lund, Sweden

2

Gambro Lundia AB, Lund, Sweden

*Correspondence: Address:?Dr Marcus Broman?Department of Anaesthesiology and Intensive Care?Lund University Hospital?S?221 85 Lund?Sweden?e?mail: marcus.broman@skane.se

Publication HistoryArticle first published online: 29 OCT 2010Accepted for publication 21 September 2010 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (252K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Get PDF (252K)

Background: Hypophosphatemia occurs in up to 80% of the patients during continuous renal replacement therapy (CRRT). Phosphate supplementation is time?consuming and the phosphate level might be dangerously low before normophosphatemia is re?established. This study evaluated the possibility to prevent hypophosphatemia during CRRT treatment by using a new commercially available phosphate?containing dialysis fluid.

Methods: Forty?two heterogeneous intensive care unit patients, admitted between January 2007 and July 2008, undergoing hemodiafiltration, were treated with a new Gambro dialysis solution with 1.2?mM phosphate (Phoxilium) or with standard medical treatment (Hemosol B0). The patients were divided into three groups: group 1 (n=14) receiving standard medical treatment and intravenous phosphate supplementation as required, group 2 (n=14) receiving the phosphate solution as dialysate solution and Hemosol B0 as replacement solution and group 3 (n=14) receiving the phosphate?containing solution as both dialysate and replacement solutions.

Results: Standard medical treatment resulted in hypophosphatemia in 11 of 14 of the patients (group 1) compared with five of 14 in the patients receiving phosphate solution as the dialysate solution and Hemosol B0 as the replacement solution (group 2). Patients treated with the phosphate?containing dialysis solution (group 3) experienced stable serum phosphate levels throughout the study. Potassium, ionized calcium, magnesium, pH, pCO2 and bicarbonate remained unchanged throughout the study.

Conclusion: The new phosphate?containing replacement and dialysis solution reduces the variability of serum phosphate levels during CRRT and eliminates the incidence of hypophosphatemia.

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Efficacy of Diclofenac Sodium in Pain Relief after Conventional Radiofrequency Denervation for Chronic Facet Joint Pain: A Double‐Blind Randomized Controlled Trial

Efficacy of Diclofenac Sodium in Pain Relief after Conventional Radiofrequency Denervation for Chronic Facet Joint Pain: A Double?Blind Randomized Controlled Trial - Ma - 2010 - Pain Medicine - Wiley Online LibrarySkip to Main Content

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DOI: 10.1111/j.1526-4637.2010.00978.x

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How to CiteMa, K., Yiqun, M., Wu, T., Wang, W., Liu, X., Huang, X. and Wang, Y. , Efficacy of Diclofenac Sodium in Pain Relief after Conventional Radiofrequency Denervation for Chronic Facet Joint Pain: A Double?Blind Randomized Controlled Trial. Pain Medicine, no. doi: 10.1111/j.1526-4637.2010.00978.x

Author Information1

Department of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai

2

Department of Acupuncture Massage and Traumatology, The Shanghai Sixth People's Hospital, Shanghai JiaoTong University, Shanghai

3

College of Pharmacy, Anhui Medical University, Hefei, China

*Correspondence: Yingwei Wang PhD,

*Correspondence: Yingwei Wang, PhD, Department of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. Tel: 86?21?65790000 ext 7951; Fax: 86?21?65153984; E?mail: wangyingwei@yahoo.com.

Publication HistoryArticle first published online: 28 OCT 2010 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (456K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Get PDF (456K) Keywords:Low Facet Pain;Radiofrequency;Diclofenac Sodium;Visual Analgesia Score;Oswestry Disability IndexAbstract

Objectives.? Many patients experience pain for a short duration after conventional radiofrequency (CRF) denervation for lumbar facet pain. The aim of the present study was to evaluate the efficacy and cost of administering diclofenac sodium for the relief of pain after CRF denervation.

Methods.? After denervation, 66 patients were randomly allocated into three groups to receive either placebo for 7 days (group A), diclofenac sodium for 3 days (group B), or diclofenac sodium for 7 days (Group C). The patients' pain visual analgesia score (VAS) and side effect were recorded at baseline 1, 7, 14, 30, and 60 days after treatment. Oswestry Disability Index (ODI), Patients' Satisfaction Score (PSS), and dosage and cost of the drugs used for pain management were recorded at baseline, 30 and 60 days after treatment.

Results.? VAS in groups B and C both was less than that in group A at 1 and 7 days after treatment (P???>?0.05). The cost of analgesic administration in group B was significantly less than in groups A and C (P?

Conclusion.? Diclofenac sodium administration improves analgesia and the PSS after CRF denervation. Compared to a 7?day dosage, a 3?day diclofenac sodium therapy has similar efficacy and less cost for the treatment of pain after CRF neurotomy. [ISRCTN68542008].

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Copyright ? 1999-2010 John Wiley & Sons, Inc. All Rights Reserved.

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Study Looks At Ways To Prevent Memory Loss Caused By Anesthetics During Recovery From Surgery


Main Category: Pain / Anesthetics
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Memory loss after anesthesia is a common adverse event upon awakening from surgery. Unfortunately the cause of such memory loss is unknown and there are no known treatments or prevention strategies. A study published in the November 2010 issue of Anesthesiology indicates that this memory loss could be prevented by blocking a receptor thought to contribute to memory deficits. Such a treatment may be able to solve the feeling of mental confusion that surgical patients so often feel shortly after coming out of anesthesia.

Memory impairment is an especially common occurrence in the elderly. Around 47 percent of elderly patients who underwent general anesthesia for minor surgical procedures exhibit memory deficits for at least 24 hours after surgery. Some of these deficits can linger: cognitive impairment, including memory loss, is present in 31-47 percent of patients at the time of hospital discharge.

Why memory loss happens, how severe it is, and how long it takes to recover remain poorly understood.

In the current study, Beverley A. Orser, M.D., Ph.D., F.R.C.P.C. and her research team at Sunnybrook Health Sciences Centre and Mount Sinai Hospital looked at two groups of anesthetized mice - one treated with a drug that inhibits a known memory-blocking receptor, and one treated with a control solution.

"When tested 30 minutes and at one day after anesthetic exposure, the mice in the control group exhibited a memory deficit that was not observed in the mice treated with the blocking compound," said Dr. Orser. "We found that the memory deficit in the post-anesthetic period could be completely prevented by treatment with a drug that inhibits the memory-blocking receptor."

Studies in patients involving anesthetics and their effects on memory are especially difficult, said Dr. Orser, because of the inability to disentangle the effects of anesthetics from other factors that can cause memory deficit. Therefore, animal models are important for helping to identify types of learning and memory susceptible to impairment and to identify certain molecular mechanisms.

Dr. Orser's study underscores the need for human clinical trials that will assess memory performance soon after surgery.

"In practical terms, our study suggests the need to re-evaluate and study the assumption that patients will remember important information given to them after surgery," said Dr. Orser. "Until such studies are performed, it seems prudent to use strategies such as written information or sharing information with family members to ensure that instructions are learned and remembered."

Source:
American Society of Anesthesiologists

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An Unusual Cause of Chronic Lumbar Back Pain: Retained Surgical Gauze Discovered after 40 Years

An Unusual Cause of Chronic Lumbar Back Pain: Retained Surgical Gauze Discovered after 40 Years - Rajkovi? - 2010 - Pain Medicine - Wiley Online LibrarySkip to Main Content

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DOI: 10.1111/j.1526-4637.2010.00969.x

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Pain MedicinePain MedicineEarly View (Articles online in advance of print)

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How to CiteRajkovi?, Z., Altarac, S. and Pape?, D. , An Unusual Cause of Chronic Lumbar Back Pain: Retained Surgical Gauze Discovered after 40 Years. Pain Medicine, no. doi: 10.1111/j.1526-4637.2010.00969.x

Author Information1

Departments of Surgery

2

Urology, Zabok General Hospital, Zabok, Croatia

*Correspondence: Zoran Rajkovi? MD,

*Correspondence: Zoran Rajkovi?, MD, Institutional address: Zabok General Hospital, Bra?ak 8,?49210?Zabok, Croatia, Home address: Bene?i?eva 7,?10000?Zagreb, Croatia. Tel: +385?98?719260; Fax: +385?1?6145400; E?mail: zrajkovi@gmail.com.

Publication HistoryArticle first published online: 28 OCT 2010 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (298K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Get PDF (298K) Keywords:Retained Gauze;Textilloma;Gossypiboma;Lumbar Back;Chronic PainAbstract

Objective.? Retained surgical gauze left inside the patient during a surgical procedure is called textiloma or gossypiboma. Most often found in abdominal and pelvic cavities, retained gauze can cause a variety of symptoms, including fever, palpable mass and pain. Symptoms depend on the location (and possible migration) of the retained gauze and local tissue reaction (inflammatory or aseptic).

Design.? Case report.

Setting and Patients.? We present a case of a patient with lumbar pain and constipation caused by surgical gauze mimicking a tumor, which was retained from previous abdominal surgery performed almost 40 years prior.

Measures.? We discuss the diagnosis, treatment and prevention of retained surgical gauze.

Conclusion.? Retained surgical gauze occurrences are not as rare as they are widely considered to be, and clinicians should be aware of that. In reality, retained gauze can be extremely difficult to diagnose, especially if a patient presents after a very long asymptomatic period.

View Full Article (HTML) Get PDF (298K) More content like this Find more content: like this article Find more content written by:Zoran Rajkovi?Silvio AltaracDino Pape?All Authors ABOUT USHELPCONTACT USAGENTSADVERTISERSMEDIAPRIVACYTERMS & CONDITIONSSITE MAP

Copyright ? 1999-2010 John Wiley & Sons, Inc. All Rights Reserved.

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Forecasting the need for medical specialists in Spain: application of a system dynamics model

Open AccessMethodology Patricia Barber email and Beatriz Gonzalez Lopez-Valcarcel email

Human Resources for Health 2010, 8:24doi:10.1186/1478-4491-8-24

Spain has gone from a surplus to a shortage of medical doctors in very few years. Medium and long-term planning for health professionals has become a high priority for health authorities.

We created a supply and demand-need simulation model for 43 medical specialties using system dynamics. The model includes demographic, education and labour market variables. Several scenarios were defined. Variables controllable by health planners can be set as parameters to simulate different scenarios. The model calculates the supply and the deficit or surplus. Experts set the ratio of specialists needed per 1000 inhabitants with a Delphi method.

In the scenario of the baseline model with moderate population growth, the deficit of medical specialists will grow from 2% at present (2800 specialists) to 14.3% in 2025 (almost 21 000). The specialties with the greatest medium-term shortages are Anesthesiology, Orthopedic and Traumatic Surgery, Pediatric Surgery, Plastic Aesthetic and Reparatory Surgery, Family and Community Medicine, Pediatrics, Radiology, and Urology.

The model suggests the need to increase the number of students admitted to medical school. Training itineraries should be redesigned to facilitate mobility among specialties. In the meantime, the need to make more flexible the supply in the short term is being filled by the immigration of physicians from new members of the European Union and from Latin America.

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Thursday, November 4, 2010

Anesthesiologists Suggest Airway Management Device As Intubation Alternative

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Manual versus mechanical cardiopulmonary resuscitation. An experimental study in pigs.

Optimal manual closed chest compressions are difficult to give. A mechanical compression/decompression device, named LUCAS, is programmed to give compression according to the latest international guidelines (2005) for cardiopulmonary resuscitation (CPR). The aim of the present study was to compare manual CPR with LUCAS-CPR.

30 kg pigs were anesthetized and intubated. After a base-line period and five minutes of ventricular fibrillation, manual CPR (n=8) or LUCAS-CPR (n=8) was started and run for 20 minutes. Professional paramedics gave manual chest compression's alternating in 2-minute periods. Ventilation, one breath for each 10 compressions, was given to all animals. Defibrillation and, if needed, adrenaline were given to obtain a return of spontaneous circulation (ROSC).

The mean coronary perfusion pressure was significantly (p<0.01) higher in the mechanical group, around 20 mmHg, compared to around 5 mmHg in the manual group. In the manual group 54 rib fractures occurred compared to 33 in the LUCAS group (p<0.01). In the manual group one severe liver injury and one pressure pneumothorax were also seen. All 8 pigs in the mechanical group achieved ROSC, as compared with 3 pigs in the manual group.

LUCAS-CPR gave significantly higher coronary perfusion pressure and significantly fewer rib fractures than manual CPR in this porcine model.

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Do we really need another biomarker to diagnose myocardial infarction after coronary artery bypass graft surgery?

Sorry, I could not read the content fromt this page.

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Anaesthesia for urgent and emergency surgery

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Sugammadex in anesthesia practice

Sugammadex in anesthesia practiceNovember 2010, Vol. 11, No. 16 , Pages 2759-2771 (doi:10.1517/14656566.2010.528391) Philippe Duvaldestin ? & Benoit Plaud Service d'Anesth?sie, R?animation Chirurgicale, SAMU 94–SMUR, Groupe Hospitalier et Universitaire Albert-Chenevier–Henri-Mondor, 51, avenue du Mar?chal-de-Lattre-de-Tassigny, 94010 Cr?teil Cedex, France +33 0149 812 111 # 35901; +33 0149 814 348; philippe.duvaldestin@hmn.aphp.fr

Importance of the field: Neuromuscular blocking agents are currently used during anesthesia but put patients at risk of postoperative paralysis. If the residual neuromuscular blockade is not reversed properly at the end of anesthesia, there is a risk of hypoxemia and pulmonary complication. Sugammadex is able to fully reverse different degrees of neuromuscular blockade induced by steroidal neuromuscular blocking agents.

Areas covered in this review: This review provides a background to the use of neuromuscular blocking agents during anesthesia. It also describes the mechanism of reversal and the clinical efficacy of sugammadex, and discusses the future changes in clinical anesthesia induced by this new selective binding agent.

What the reader will gain: An understanding of the rationale and use of sugammadex as a reversal agent of different degrees of neuromuscular blockade and the use of the high-dose rocuronium–sugammadex combination as an alternative to succinylcholine for rapid sequence induction.

Take home message: Sugammadex provides an original mechanism of reversing the effect of neuromuscular steroidal agent by direct inactivation in plasma. Although its effect is spectacular, it is questionable whether this drug will change current practice.

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S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle

Am J Physiol Cell Physiol 299: C891-C902, 2010. First published August 4, 2010; doi:10.1152/ajpcell.00180.2010
0363-6143/10 $8.00

Muscle Cell Biology and Cell Motility

Benjamin L. Prosser,1 Erick O. Hern?ndez-Ochoa,2 Richard M. Lovering,3 Zoita Andronache,4 Danna B. Zimmer,5 Werner Melzer,4 and Martin F. Schneider2

1Center for Biomedical Engineering and Technology (BioMET), 2Department of Biochemistry and Molecular Biology, 3Department of Physiology, University of Maryland, Baltimore, Maryland; 4Institute of Applied Physiology, Ulm University, Ulm, Germany; 5Department of Veterinary Pathobiology, College of Veterinary Medicine and Integrative Biosciences, Texas A&M University, College Station, Texas

Submitted 14 May 2010 ; accepted in final form 2 August 2010

The role of S100A1 in skeletal muscle is just beginning to be elucidated. We have previously shown that skeletal muscle fibers from S100A1 knockout (KO) mice exhibit decreased action potential (AP)-evoked Ca2+ transients, and that S100A1 binds competitively with calmodulin to a canonical S100 binding sequence within the calmodulin-binding domain of the skeletal muscle ryanodine receptor. Using voltage clamped fibers, we found that Ca2+ release was suppressed at all test membrane potentials in S100A1–/– fibers. Here we examine the role of S100A1 during physiological AP-induced muscle activity, using an integrative approach spanning AP propagation to muscle force production. With the voltage-sensitive indicator di-8-aminonaphthylethenylpyridinium, we first demonstrate that the AP waveform is not altered in flexor digitorum brevis muscle fibers isolated from S100A1 KO mice. We then use a model for myoplasmic Ca2+ binding and transport processes to calculate sarcoplasmic reticulum Ca2+ release flux initiated by APs and demonstrate decreased release flux and greater inactivation of flux in KO fibers. Using in vivo stimulation of tibialis anterior muscles in anesthetized mice, we show that the maximal isometric force response to twitch and tetanic stimulation is decreased in S100A1–/– muscles. KO muscles also fatigue more rapidly upon repetitive stimulation than those of wild-type counterparts. We additionally show that fiber diameter, type, and expression of key excitation-contraction coupling proteins are unchanged in S100A1 KO muscle. We conclude that the absence of S100A1 suppresses physiological AP-induced Ca2+ release flux, resulting in impaired contractile activation and force production in skeletal muscle.

S100; excitation-contraction coupling; calcium signaling; muscle
Address for reprint requests and other correspondence: M. F. Schneider, 108 N. Greene St., Baltimore, MD 21201 (e-mail: mschneid{at}umaryland.edu ). Copyright ? 2010 by the American Physiological Society.

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Penile blood pressure monitoring for a pediatric patient with hypomelia.

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Wednesday, November 3, 2010

High Resource Use Found for Chronic Neck Pain (CME/CE)

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By Nancy Walsh, Staff Writer, MedPage Today
Published: October 28, 2010
Reviewed by Dori F. Zaleznik, MD; Associate Clinical Professor of Medicine, Harvard Medical School, Boston and
Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner Patients with chronic neck pain are overutilizing unproven and questionable therapies and underusing modalities for which there is evidence, a telephone survey found.

For instance, almost one-third of patients were taking strong narcotics, despite the fact that the evidence for medications in neck pain is "extremely limited," wrote Adam P. Goode, DPT, of Duke University, and colleagues.

In contrast, only about half had been prescribed therapeutic exercises during the past year -- a treatment for which a Cochrane review found good evidence, the researchers observed online in Arthritis Care & Research.

"Like chronic low back pain, chronic neck pain is often unresponsive to treatment and costly in regard to direct and indirect costs," the researchers noted.

Because few data are available on healthcare usage for chronic neck pain, they conducted a telephone survey in North Carolina, contacting 5,357 households with 9,924 adults, querying them about family members with chronic, impairing neck pain.

This was defined as pain and interference with activities almost every day for the past three months, or more than 24 episodes of pain persisting for at least a day during the past year.

They identified 135 patients who met the criteria, giving a point prevalence for North Carolina of 2.2% (95% CI 1.7 to 2.6).

This meant that there could be almost 195,000 adults in the state who had neck pain severe enough to interfere with their activities, according to the researchers.

More than half of the patients were women, the majority were non-Hispanic white, and mean age was 48.9 years. Fewer than 10% had less than a high school education.

Mean pain score on a 10-point scale for the past three months was 6.2 (95% CI 5.7 to 6.6), and mean duration of pain was 6.9 years (95% CI 5.4 to 8.3).

The mean neck disability index score was 31.5 (95% CI 28.9 to 34.1) out of a possible 50.

On the physical component of the short form-12 evaluation of health status, the mean score was 38.6, while the mean score on the mental component was 50.3.

A total of 55.6% reported having had depressed mood.

With regard to healthcare utilization, 79.3% had consulted at least one provider for their neck pain during the previous year, and among these patients, more than 90% had seen a physician: Primary care physician, 72%Orthopedic surgeon, 31.6%Neurosurgeon, 29.1%Neurologist, 22.8%

In addition, 40% saw a chiropractor, 35.2% consulted a physical therapist, and 41% visited an alternative medicine specialist such as a massage therapist.

Frequent consultation with multiple types of providers was common, with an average of five providers per patient and 21 visits.

Imaging tests also were prevalent, with 45% of patients having had x-rays, often more than once, as well as 24% having CT scans and 30% undergoing MRI.

The researchers commented that this use of diagnostic imaging techniques did not appear to be in line with recommendations for clinical decision-making.

"One may also question the value of imaging techniques for subjects with an average duration of symptoms of 6.9 years, as this duration of symptoms may decrease the likelihood that findings would lead to clinically important inferences," they wrote.

The strong narcotics used included oxycodone, fentanyl, and methadone, while weaker narcotics such as codeine and propoxyphene had been taken by 23.1% (95% CI 15 to 33.7). Almost one-third used muscle relaxants.

Other treatment modalities favored by patients included heat, cold, and massage, which were reported by 57%, 47.7%, and 28.1%, respectively -- despite there being little or no evidence in their favor.

In contrast, rehabilitation conditioning/work hardening and acupuncture -- both of which have some positive evidence -- were used by the fewest patients, at 2.7% and 3.9%, respectively.

The authors noted that there are various possible explanations for the discrepancies between treatments used and available evidence, including the complexity of neck pain, patients' high expectations of technology, reimbursement problems, and inadequate knowledge of evidence by providers.

Potential shortcomings of the study include its limitation to patients with chronic neck pain without lower back pain, which commonly occur together.

It also included only participants from one state, and was cross-sectional in design.

In addition, it relied on patient recall for tests and treatments, which could have resulted in over- or underestimations.

The researchers concluded that this patient population exhibits high use of healthcare resources, yet continues to have considerable disability.

The study was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

The authors had no other financial disclosures.

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Contribute your own thoughts, experience, questions, and knowledge to this story for the benefit of all MedPage Today readers.Add Your Knowledge Add Your Knowledgejoseph biundo - Oct 29, 2010
It is unfortunate that the two specialities that might be able to better evaluate and treat chronic neck pain are not even mentioned, and these are Rheumatology and also Physical Medicine & Rehabilitation. These two specialities are more likely to identify such problems as fibromyalgia, polymyalgia rheumatica or inflammatory arthritis, which also cause chronic neck pain. Too, these specialities are more likely to prescribe physical therapy and rely less on narcotics for treatment. Joseph Biundo, MD

Add Your KnowledgeEric Robertson, PT, DPT - Oct 29, 2010
The discrepancy between evidence-supported interventions and the actual interventions performed is certainly a problem for many musculoskeletal conditions. Congratulations to the authors for bringing attention to this issue. In addition to the Cochrane review which supports therapeutic exercise for neck pain, there is also a clinical practice guideline publicly available which highlights those examination and intervention strategies supported by high quality evidence. This guideline can be found at http://www.guidelines.gov/content.aspx? id=14703. Furthermore, a recent high-quality randomized clinical trial by Walker et al. published in Spine (October 2008), highlighted the effectiveness of joint mobilization and manipulation added to an exercise program. Not only did the hands-on treatment prove more effective in reducing neck pain, those individuals who received manual therapy had a much lower utilization of other health resources. Research like this study from Goode et al., certainly brings to light the over-allocation of high- cost medical resources and supports increased ease of access to providers like physical therapists who provide evidence-based interventions for patients with neck pain.

Add Your KnowledgeJanet Peterson, Chronic Pain Patient - Oct 29, 2010
Thankfully, I don't have neck pain. I have back pain. T-8 thru T-12/L-1 hernations. I don't see in here any mention of questions related to, or breakdown of reasons WHY these people may have neck pain. I'd love to know why that is? Most certainly, until we have actually unraveled the truly complex process called pain, there will be "high use of healthcare resources, yet continues to have considerable disability." This can be for a great number of reasons. The one that comes to mind that seems to be skewed here, is the number of diagnostic tools used. MRI, CT, XRAY etc. These are not being done at 6.9 mean years of having had the pain, they were done within the first year of the pain not subsiding with exercise, physical therapy, nsaids, and other common remedies first tried when a patient presents with pain. Now, back to the reasons behind the pain. No mention of what's been found with all the diagnostics. How many have hernieated cervical vertebrae? How many have pinched nerves? How many have tried surgical intervention without resolution? How many have this neck pain as a result of trauma such as a car crash? I can say as a patient with pain not easily identifiable by swelling or blood present, that ALL of these are what is prescribed as the Dr's try to find not only the reason for the pain, but the relief of that pain. All of the diagnostics mentioned, all of the possible physical exercises encompassed by both the orthodox and unorthodox western medicine, from physical therapy to accupunture, all of the relief measures such as hot, and cold, exercises, physical rehab, narcotics, everything, is how modern medicine tries to treat a chronic pain patient. Any patient taking most of the higher narcotics mentioned are visiting their Dr's anywhere from once a month to once every three months, in compliance with measures put in place to protect both the Dr. and the patient. There was no mention of the diagnosis given to all of these patients either. How many have been told by thosee neurosurgeons that this is it. There is no surgery, there is not treatment, there is nothing more to be done accept to treat the pain as best they can, and for the patient to put in place any measures that they have found seem to help them personally, such as heat or cold. They encourage the exercises given by the physical therapists, but they also know that those patients have met their health care insurance's limits on actual visits to those professionals. I guess what surprised me the very most, is that being what I considered a patient very interested in my own health and healthcare, I have done everything mentioned in here, and more, with my health care providers opinion being a very large factor, and my own research into my own condition, and yet I'm reading that none of this is either in line, or effective? At least for neck pain? I find it so surprising because I believe that this is how most pain that isn't acute IS treated by our health care providers, regardless of pain site, or cause, i.e. trauma, deterioration, etc. Now my case may be different, in that there is no surgery, no cure, no treament for the problem itself, but it sounds as if the way my healthcare professionals approached this, is exactly the same. Please let me say that no, I am not a doctor. I may not have been able to read this particular article correctly, but this is what I did take away from it. If I've been mistaken in what I understood, I apologize, and I won't need any more than one doctor to let me know how much I don't understand lol. Please?

Add Your Knowledgejoseph biundo - Oct 29, 2010
It is unfortunate that the two specialities that might be able to better evaluate and treat chronic neck pain are not even mentioned, and these are Rheumatology and also Physical Medicine & Rehabilitation. These two specialities are more likely to identify such problems as fibromyalgia, polymyalgia rheumatica or inflammatory arthritis, which also cause chronic neck pain. Too, these specialities are more likely to prescribe physical therapy and rely less on narcotics for treatment. Joseph Biundo, MD

Add Your KnowledgeEric Robertson, PT, DPT - Oct 29, 2010
The discrepancy between evidence-supported interventions and the actual interventions performed is certainly a problem for many musculoskeletal conditions. Congratulations to the authors for bringing attention to this issue. In addition to the Cochrane review which supports therapeutic exercise for neck pain, there is also a clinical practice guideline publicly available which highlights those examination and intervention strategies supported by high quality evidence. This guideline can be found at http://www.guidelines.gov/content.aspx? id=14703. Furthermore, a recent high-quality randomized clinical trial by Walker et al. published in Spine (October 2008), highlighted the effectiveness of joint mobilization and manipulation added to an exercise program. Not only did the hands-on treatment prove more effective in reducing neck pain, those individuals who received manual therapy had a much lower utilization of other health resources. Research like this study from Goode et al., certainly brings to light the over-allocation of high- cost medical resources and supports increased ease of access to providers like physical therapists who provide evidence-based interventions for patients with neck pain.

Add Your KnowledgeJanet Peterson, Chronic Pain Patient - Oct 29, 2010
Thankfully, I don't have neck pain. I have back pain. T-8 thru T-12/L-1 hernations. I don't see in here any mention of questions related to, or breakdown of reasons WHY these people may have neck pain. I'd love to know why that is? Most certainly, until we have actually unraveled the truly complex process called pain, there will be "high use of healthcare resources, yet continues to have considerable disability." This can be for a great number of reasons. The one that comes to mind that seems to be skewed here, is the number of diagnostic tools used. MRI, CT, XRAY etc. These are not being done at 6.9 mean years of having had the pain, they were done within the first year of the pain not subsiding with exercise, physical therapy, nsaids, and other common remedies first tried when a patient presents with pain. Now, back to the reasons behind the pain. No mention of what's been found with all the diagnostics. How many have hernieated cervical vertebrae? How many have pinched nerves? How many have tried surgical intervention without resolution? How many have this neck pain as a result of trauma such as a car crash? I can say as a patient with pain not easily identifiable by swelling or blood present, that ALL of these are what is prescribed as the Dr's try to find not only the reason for the pain, but the relief of that pain. All of the diagnostics mentioned, all of the possible physical exercises encompassed by both the orthodox and unorthodox western medicine, from physical therapy to accupunture, all of the relief measures such as hot, and cold, exercises, physical rehab, narcotics, everything, is how modern medicine tries to treat a chronic pain patient. Any patient taking most of the higher narcotics mentioned are visiting their Dr's anywhere from once a month to once every three months, in compliance with measures put in place to protect both the Dr. and the patient. There was no mention of the diagnosis given to all of these patients either. How many have been told by thosee neurosurgeons that this is it. There is no surgery, there is not treatment, there is nothing more to be done accept to treat the pain as best they can, and for the patient to put in place any measures that they have found seem to help them personally, such as heat or cold. They encourage the exercises given by the physical therapists, but they also know that those patients have met their health care insurance's limits on actual visits to those professionals. I guess what surprised me the very most, is that being what I considered a patient very interested in my own health and healthcare, I have done everything mentioned in here, and more, with my health care providers opinion being a very large factor, and my own research into my own condition, and yet I'm reading that none of this is either in line, or effective? At least for neck pain? I find it so surprising because I believe that this is how most pain that isn't acute IS treated by our health care providers, regardless of pain site, or cause, i.e. trauma, deterioration, etc. Now my case may be different, in that there is no surgery, no cure, no treament for the problem itself, but it sounds as if the way my healthcare professionals approached this, is exactly the same. Please let me say that no, I am not a doctor. I may not have been able to read this particular article correctly, but this is what I did take away from it. If I've been mistaken in what I understood, I apologize, and I won't need any more than one doctor to let me know how much I don't understand lol. Please?



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