Efficacy of Diclofenac Sodium in Pain Relief after Conventional Radiofrequency Denervation for Chronic Facet Joint Pain: A Double?Blind Randomized Controlled Trial - Ma - 2010 - Pain Medicine - Wiley Online LibrarySkip to Main Content
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Efficacy of Diclofenac Sodium in Pain Relief after Conventional Radiofrequency Denervation for Chronic Facet Joint Pain: A Double?Blind Randomized Controlled TrialKe Ma PhD1, Mi Yiqun MS2, Tao Wu MS1, Wenhao Wang MS1, Xiaoming Liu PhD1, Xiaohui Huang PhD3, Yingwei Wang PhD1,*Article first published online: 28 OCT 2010DOI: 10.1111/j.1526-4637.2010.00978.xWiley Periodicals, Inc. Issue
Pain MedicineEarly View (Articles online in advance of print)Additional InformationHow to CiteMa, K., Yiqun, M., Wu, T., Wang, W., Liu, X., Huang, X. and Wang, Y. , Efficacy of Diclofenac Sodium in Pain Relief after Conventional Radiofrequency Denervation for Chronic Facet Joint Pain: A Double?Blind Randomized Controlled Trial. Pain Medicine, no. doi: 10.1111/j.1526-4637.2010.00978.xAuthor Information1
Department of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai
2
Department of Acupuncture Massage and Traumatology, The Shanghai Sixth People's Hospital, Shanghai JiaoTong University, Shanghai
3
College of Pharmacy, Anhui Medical University, Hefei, China
*Correspondence: Yingwei Wang PhD, *Correspondence: Yingwei Wang, PhD, Department of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. Tel: 86?21?65790000 ext 7951; Fax: 86?21?65153984; E?mail: wangyingwei@yahoo.com. Publication HistoryArticle first published online: 28 OCT 2010 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (456K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Get PDF (456K) Keywords:Low Facet Pain;Radiofrequency;Diclofenac Sodium;Visual Analgesia Score;Oswestry Disability IndexAbstract
Objectives.? Many patients experience pain for a short duration after conventional radiofrequency (CRF) denervation for lumbar facet pain. The aim of the present study was to evaluate the efficacy and cost of administering diclofenac sodium for the relief of pain after CRF denervation.
Methods.? After denervation, 66 patients were randomly allocated into three groups to receive either placebo for 7 days (group A), diclofenac sodium for 3 days (group B), or diclofenac sodium for 7 days (Group C). The patients' pain visual analgesia score (VAS) and side effect were recorded at baseline 1, 7, 14, 30, and 60 days after treatment. Oswestry Disability Index (ODI), Patients' Satisfaction Score (PSS), and dosage and cost of the drugs used for pain management were recorded at baseline, 30 and 60 days after treatment.
Results.? VAS in groups B and C both was less than that in group A at 1 and 7 days after treatment (P???>?0.05). The cost of analgesic administration in group B was significantly less than in groups A and C (P?
Conclusion.? Diclofenac sodium administration improves analgesia and the PSS after CRF denervation. Compared to a 7?day dosage, a 3?day diclofenac sodium therapy has similar efficacy and less cost for the treatment of pain after CRF neurotomy. [ISRCTN68542008].
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Go to main page content home current query previous queries CME subscribe ONLINE using send to (A) and (A) activate my account search go advanced search? user name password characters in N2O emissions and long-term morbidity and mortality in the ENIGMA trial Kate Leslie, MBBS, MD, MEpi, FANZCA *, Paul s. Myles, MBBS, MD, MPH, FANZCA, FCARSCI, FRCA ?, Matthew t. v. Chan, MBBSFANZCA ?, Andrew Forbes, MSc, PhD, Michael j. Paech, MBBS, DM, DRCOG, FRCA, FANZCA, FFPMANZCA, FRANZCOG (She) ?, Philip Peyton, MBBS, MD, FANZCA, Brendan p. Silbert, MBBS, FANZCA # and Elizabeth Williamson, PhD **Authors' affiliations are listed at the end of the article. Address correspondence to Kate Leslie, MBBS, MD, MEpi, FANZCA, Parkville, Victoria, 3050, Australia. Address e-mail to kate.leslie{at}mh.org.au. Abstract BACKGROUND: There is a plausible pathophysiologic rationale for increased long-term cardiovascular morbidity and mortality in patients receiving significant exposure to nitrous oxide. However, this relationship has not been established clinically. The ENIGMA trial randomized 2050 patients having noncardiac surgery lasting more than 2 hours to nitrous oxide–based or nitrous oxide–free anesthesia. We conducted a follow-up study of the ENIGMA patients to evaluate the risk of cardiovascular events in the longer term. METHODS: The trial case report forms and medical records of all study patients were reviewed. The date and cause of death and occurrence of myocardial infarction or stroke were recorded. A telephone interview was then conducted with all surviving patients. The primary endpoint of the study was survival. RESULTS: The median follow-up time was 3.5 (range: 0 to 5.7) years. Three hundred eighty patients (19%) had died since the index surgery, 91 (4.5%) were recorded as having myocardial infarction, and 44 (2.2%) had a stroke during the entire follow-up period. Nitrous oxide did not significantly increase the risk of death [hazard ratio = 0.98 (95% confidence interval, CI: 0.80 to 1.20; P = 0.82)]. The adjusted odds ratio for myocardial infarction in patients administered nitrous oxide was 1.59 (95% CI: 1.01 to 2.51; P = 0.04) and for stroke was 1.01 (95% CI: 0.55 to 1.87; P = 0.97). CONCLUSIONS: The administration of nitrous oxide was associated with increased long-term risk of myocardial infarction, but not of death or stroke in patients enrolled in the ENIGMA trial. The exact relationship between nitrous oxide administration and serious long-term adverse outcomes will require confirmation by an appropriately designed large randomized controlled trial. Footnotes This study was supported by a project grant from the Australian and New Zealand College of Anaesthetists and a direct grant for research from the Chinese University of Hong Kong (project #2041315). The ENIGMA Trial was funded by the National Health and Medical Research Council of Australia (236956). Accepted August 5, 2010. Copyright ? 2011 International Anesthesia Research Society ? Previous | Next Article ?Table of Contents This Article Published online before print September 22, 2010, doi: 10.1213/?ANE.0b013e3181f7e2c4 A & A February 2011 vol. 112 no. 2 387-393 ? Abstract Full Text Full Text (PDF) Classifications Patient Safety Services Email this article to a colleague Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in PubMed Download to citation manager Request Permissions Citing Articles Load citing article information Google Scholar Articles by Leslie, K. Articles by Williamson, E. Search for related content PubMed PubMed citation Articles by Leslie, K. Articles by Williamson, E. Related Content Cardiovascular Complications Outcomes Patient Safety Pharmacology Load related web page information Current Issue July 2011, 113 (1) 
Alert me to new issues of A & A Join the IARS About A&A Mission Editorial Board For Authors For Reviewers Cover Art Sign up Sign up for eTOCs Sign up for RSS feeds Browse by Topic Permissions and Copyright Press Room OpenAnesthesia Advertise in A&A Career Center Most Read Special Article: 2010 Anesthesia & Analgesia Guide for Authors: 2009-2010 Editorial Board, Anesthesia & Analgesia Hand Contamination of Anesthesia Providers Is an Important Risk Factor for Intraoperative Bacterial Transmission Postoperative Sore Throat: More Answers Than Questions Nitrous Oxide and Long-Term Morbidity and Mortality in the ENIGMA Trial Surgical Site Infections and the Anesthesia Professionals' Microbiome: We've All Been Slimed! Now What Are We Going to Do About It? ? View all Most Read articles Cited ASE/SCA Guidelines for Performing a Comprehensive Intraoperative Multiplane Transesophageal Echocardiography Examination: Recommendations of the American Society of Echocardiography Council for Intraoperative Echocardiography and the Society of Cardiovascular Anesthesiologists Task Force for Certification in Perioperative Transesophageal Echocardiography The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials Consensus Guidelines for Managing Postoperative Nausea and Vomiting Cerebral Autoregulation and Flow/Metabolism Coupling during Cardiopulmonary Bypass: The Influence of Paco2 A Postanesthetic Recovery Score ? View all Most Cited articles Copyright ? 2011 by the International Anesthesia Research Society Print ISSN: 0003-2999 Online ISSN: 1526-7598 
Alert me to new issues of A & A Join the IARS About A&A Mission Editorial Board For Authors For Reviewers Cover Art Sign up Sign up for eTOCs Sign up for RSS feeds Browse by Topic Permissions and Copyright Press Room OpenAnesthesia Advertise in A&A Career Center Most Read Special Article: 2010 Anesthesia & Analgesia Guide for Authors: 2009-2010 Editorial Board, Anesthesia & Analgesia Hand Contamination of Anesthesia Providers Is an Important Risk Factor for Intraoperative Bacterial Transmission Postoperative Sore Throat: More Answers Than Questions Nitrous Oxide and Long-Term Morbidity and Mortality in the ENIGMA Trial Surgical Site Infections and the Anesthesia Professionals' Microbiome: We've All Been Slimed! Now What Are We Going to Do About It? ? View all Most Read articles Cited ASE/SCA Guidelines for Performing a Comprehensive Intraoperative Multiplane Transesophageal Echocardiography Examination: Recommendations of the American Society of Echocardiography Council for Intraoperative Echocardiography and the Society of Cardiovascular Anesthesiologists Task Force for Certification in Perioperative Transesophageal Echocardiography The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials Consensus Guidelines for Managing Postoperative Nausea and Vomiting Cerebral Autoregulation and Flow/Metabolism Coupling during Cardiopulmonary Bypass: The Influence of Paco2 A Postanesthetic Recovery Score ? View all Most Cited articles Copyright ? 2011 by the International Anesthesia Research Society Print ISSN: 0003-2999 Online ISSN: 1526-7598