Designing simple PK–PD studies in children

Designing simple PK–PD studies in children - THOMSON - 2010 - Pediatric Anesthesia - Wiley Online LibrarySkip to Main Content

Home Help

PUBLICATIONSBROWSE BY SUBJECTRESOURCESABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED ?FORGOTTEN PASSWORD ?INSTITUTIONAL LOGIN > JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy JOURNAL MENU Journal Home FIND ISSUES Current IssueAll IssuesVirtual Issues FIND ARTICLES Early View GET ACCESS Subscribe / Renew FOR CONTRIBUTORS Author GuidelinesSubmit an Article ABOUT THIS JOURNAL NewsOverviewEditorial BoardPermissionsAdvertiseContact SPECIAL FEATURES 20th Anniversary CollectionWiley's Anesthesia CollectionSpecial Issue: The Pediatric Airway Designing simple PK–PD studies in childrenALISON H. THOMSON MSc, PhD, MRPharmS1,2, HENRY L. ELLIOTT MD, FRCP3Article first published online: 29 OCT 2010

DOI: 10.1111/j.1460-9592.2010.03436.x

? 2010 Blackwell Publishing Ltd

Issue

Pediatric AnesthesiaEarly View (Articles online in advance of print)

Additional Information

How to CiteTHOMSON, A. H. and ELLIOTT, H. L. , Designing simple PK–PD studies in children. Pediatric Anesthesia, no. doi: 10.1111/j.1460-9592.2010.03436.x

Author Information1

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde

2

Pharmacy and Prescribing Support Unit, Pharmacy Department, Western Infirmary

3

Education and Consulting, Anniesland, Glasgow, UK

*Correspondence: Alison H. Thomson, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G40RE, UK (email: alison.h.thomson@strath.ac.uk).

Publication HistoryArticle first published online: 29 OCT 2010Accepted 26 August 2010 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (134K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Get PDF (134K) Keywords:population approach;pediatrics;anesthetic agentsSummary

Conducting clinical pharmacology research studies in pediatric patients is challenging because of ethical and practical constraints but necessary to ensure that drugs are used safely and effectively in this population. Developments in laboratory analytical techniques, such as improved assay sensitivity and the use of alternative sample matrices, can reduce blood loss and offer less invasive blood sampling, causing less trauma to the patient and fewer ethical concerns. Recent advances in data analysis techniques, which aim to extract the maximum amount of useful information from small sample numbers, should be considered when planning a clinical trial and incorporated into the study design. Using ‘population’ methodology allows a more flexible sampling strategy that enables valuable data to be collected in the course of routine clinical practice, rather than in a rigid, and potentially artificial, setting. Integration of pharmacokinetics and pharmacodynamics and the application of physiological approaches and simulation techniques to the analysis and interpretation of drug concentration and effect data offer new opportunities that have particular relevance to pharmacological research in the field of pediatric anesthetics.

View Full Article (HTML) Get PDF (134K) More content like this Find more content: like this article Find more content written by:ALISON H. THOMSONHENRY L. ELLIOTTAll Authors ABOUT USHELPCONTACT USAGENTSADVERTISERSMEDIAPRIVACYTERMS & CONDITIONSSITE MAP

Copyright ? 1999-2010 John Wiley & Sons, Inc. All Rights Reserved.

View the original article here