Efficacy of Diclofenac Sodium in Pain Relief after Conventional Radiofrequency Denervation for Chronic Facet Joint Pain: A Double‐Blind Randomized Controlled Trial

Efficacy of Diclofenac Sodium in Pain Relief after Conventional Radiofrequency Denervation for Chronic Facet Joint Pain: A Double?Blind Randomized Controlled Trial - Ma - 2010 - Pain Medicine - Wiley Online LibrarySkip to Main Content

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PUBLICATIONSBROWSE BY SUBJECTRESOURCESABOUT US LOGIN Enter e-mail address Enter password REMEMBER ME NOT REGISTERED ?FORGOTTEN PASSWORD ?INSTITUTIONAL LOGIN > JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy JOURNAL MENU Journal Home FIND ISSUES Current IssueAll IssuesVirtual Issues FIND ARTICLES Early View GET ACCESS Subscribe / Renew FOR CONTRIBUTORS Author GuidelinesSubmit an Article ABOUT THIS JOURNAL Society InformationNewsOverviewEditorial BoardPermissionsAdvertiseContact SPECIAL FEATURES Professional OpportunitiesPainPoints Blog Efficacy of Diclofenac Sodium in Pain Relief after Conventional Radiofrequency Denervation for Chronic Facet Joint Pain: A Double?Blind Randomized Controlled TrialKe Ma PhD1, Mi Yiqun MS2, Tao Wu MS1, Wenhao Wang MS1, Xiaoming Liu PhD1, Xiaohui Huang PhD3, Yingwei Wang PhD1,*Article first published online: 28 OCT 2010

DOI: 10.1111/j.1526-4637.2010.00978.x

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How to CiteMa, K., Yiqun, M., Wu, T., Wang, W., Liu, X., Huang, X. and Wang, Y. , Efficacy of Diclofenac Sodium in Pain Relief after Conventional Radiofrequency Denervation for Chronic Facet Joint Pain: A Double?Blind Randomized Controlled Trial. Pain Medicine, no. doi: 10.1111/j.1526-4637.2010.00978.x

Author Information1

Department of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai

2

Department of Acupuncture Massage and Traumatology, The Shanghai Sixth People's Hospital, Shanghai JiaoTong University, Shanghai

3

College of Pharmacy, Anhui Medical University, Hefei, China

*Correspondence: Yingwei Wang PhD,

*Correspondence: Yingwei Wang, PhD, Department of Anesthesiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. Tel: 86?21?65790000 ext 7951; Fax: 86?21?65153984; E?mail: wangyingwei@yahoo.com.

Publication HistoryArticle first published online: 28 OCT 2010 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (456K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Get PDF (456K) Keywords:Low Facet Pain;Radiofrequency;Diclofenac Sodium;Visual Analgesia Score;Oswestry Disability IndexAbstract

Objectives.? Many patients experience pain for a short duration after conventional radiofrequency (CRF) denervation for lumbar facet pain. The aim of the present study was to evaluate the efficacy and cost of administering diclofenac sodium for the relief of pain after CRF denervation.

Methods.? After denervation, 66 patients were randomly allocated into three groups to receive either placebo for 7 days (group A), diclofenac sodium for 3 days (group B), or diclofenac sodium for 7 days (Group C). The patients' pain visual analgesia score (VAS) and side effect were recorded at baseline 1, 7, 14, 30, and 60 days after treatment. Oswestry Disability Index (ODI), Patients' Satisfaction Score (PSS), and dosage and cost of the drugs used for pain management were recorded at baseline, 30 and 60 days after treatment.

Results.? VAS in groups B and C both was less than that in group A at 1 and 7 days after treatment (P???>?0.05). The cost of analgesic administration in group B was significantly less than in groups A and C (P?

Conclusion.? Diclofenac sodium administration improves analgesia and the PSS after CRF denervation. Compared to a 7?day dosage, a 3?day diclofenac sodium therapy has similar efficacy and less cost for the treatment of pain after CRF neurotomy. [ISRCTN68542008].

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Study Looks At Ways To Prevent Memory Loss Caused By Anesthetics During Recovery From Surgery

Main Category: Pain / Anesthetics
Article Date: 27 Oct 2010 - 0:00 PDT window.fbAsyncInit = function() { FB.init({ appId: 'aa16a4bf93f23f07eb33109d5f1134d3', status: true, cookie: true, xfbml: true, channelUrl: 'http://www.medicalnewstoday.com/scripts/facebooklike.html'}); }; (function() { var e = document.createElement('script'); e.async = true; e.src = document.location.protocol + '//connect.facebook.net/en_US/all.js'; document.getElementById('fb-root').appendChild(e); }()); email to a friend   printer friendly   opinions  

Memory loss after anesthesia is a common adverse event upon awakening from surgery. Unfortunately the cause of such memory loss is unknown and there are no known treatments or prevention strategies. A study published in the November 2010 issue of Anesthesiology indicates that this memory loss could be prevented by blocking a receptor thought to contribute to memory deficits. Such a treatment may be able to solve the feeling of mental confusion that surgical patients so often feel shortly after coming out of anesthesia.

Memory impairment is an especially common occurrence in the elderly. Around 47 percent of elderly patients who underwent general anesthesia for minor surgical procedures exhibit memory deficits for at least 24 hours after surgery. Some of these deficits can linger: cognitive impairment, including memory loss, is present in 31-47 percent of patients at the time of hospital discharge.

Why memory loss happens, how severe it is, and how long it takes to recover remain poorly understood.

In the current study, Beverley A. Orser, M.D., Ph.D., F.R.C.P.C. and her research team at Sunnybrook Health Sciences Centre and Mount Sinai Hospital looked at two groups of anesthetized mice - one treated with a drug that inhibits a known memory-blocking receptor, and one treated with a control solution.

"When tested 30 minutes and at one day after anesthetic exposure, the mice in the control group exhibited a memory deficit that was not observed in the mice treated with the blocking compound," said Dr. Orser. "We found that the memory deficit in the post-anesthetic period could be completely prevented by treatment with a drug that inhibits the memory-blocking receptor."

Studies in patients involving anesthetics and their effects on memory are especially difficult, said Dr. Orser, because of the inability to disentangle the effects of anesthetics from other factors that can cause memory deficit. Therefore, animal models are important for helping to identify types of learning and memory susceptible to impairment and to identify certain molecular mechanisms.

Dr. Orser's study underscores the need for human clinical trials that will assess memory performance soon after surgery.

"In practical terms, our study suggests the need to re-evaluate and study the assumption that patients will remember important information given to them after surgery," said Dr. Orser. "Until such studies are performed, it seems prudent to use strategies such as written information or sharing information with family members to ensure that instructions are learned and remembered."

Source:
American Society of Anesthesiologists

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