Review Article: The Role of the Perioperative Period in Recurrence After Cancer Surgery

The Role of the Perioperative Period in Recurrence After Cancer Surgery Skip to main page content

HOME CURRENT ISSUE PAST ISSUES CME SUBSCRIBE ONLINE HELP SUBMIT TO A&A ACTIVATE MY ACCOUNT Search GO Advanced Search ? User Name Password Sign In The Role of the Perioperative Period in Recurrence After Cancer Surgery Antje Gottschalk, MD*?, Sonal Sharma, MD*, Justin Ford, MD*, Marcel E. Durieux, MD, PhD* and Mohamed Tiouririne, MD*

From the *Department of Anesthesia, University of Virginia, Charlottesville, Virginia; and ?Department of Anesthesiology and Intensive Care Medicine, University Muenster, Muenster, Germany. Address correspondence to Mohamed Tiouririne, MD, Department of Anesthesiology, University of Virginia, Charlottesville, VA. Address e-mail to mt9y{at}virginia.edu. Abstract A wealth of basic science data supports the hypothesis that the surgical stress response increases the likelihood of cancer dissemination and metastasis during and after cancer surgery. Anesthetic management of the cancer patient, therefore, could potentially influence long-term outcome. Preclinical data suggest that beneficial approaches might include selection of induction drugs such as propofol, minimizing the use of volatile anesthetics, and coadministration of cyclooxygenase antagonists with systemic opioids. Retrospective clinical trials suggest that the addition of regional anesthesia might decrease recurrence after cancer surgery. Other factors such as blood transfusion, temperature regulation, and statin administration may also affect long-term outcome.

Footnotes Marcel E. Durieux is section Editor of Anesthetic Pre-Clinical Pharmacology for the Journal. The manuscript was handled by Sorin J. Brull, section Editor of Patient Safety, and Dr. Durieux was not involved in any way with the editorial process or decision.

Disclosure: The authors report no conflict of interest.

Reprints will not be available from the author.

Accepted February 24, 2010. Copyright ? 2010 International Anesthesia Research Society ? Previous | Next Article ?Table of Contents This Article Published online before print April 30, 2010, doi: 10.1213/?ANE.0b013e3181de0ab6 A & A June 2010 vol. 110 no. 6 1636-1643 ? Abstract Full Text Full Text (PDF) CME Classifications Series: Review Article Patient Safety Services Email this article to a colleague Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in PubMed Download to citation manager Request Permissions Citing Articles Load citing article information Citing articles via Google Scholar Google Scholar Articles by Gottschalk, A. Articles by Tiouririne, M. Search for related content PubMed PubMed citation Articles by Gottschalk, A. Articles by Tiouririne, M. Related Content Mechanisms Outcomes Patient Safety Pharmacology Load related web page information Current Issue June 2011, 112 (6) Alert me to new issues of A & A Join the IARS About A&A Mission Editorial Board For Authors For Reviewers Cover Art Sign up Sign up for eTOCs Sign up for RSS feeds Browse by Topic Permissions and Copyright Press Room OpenAnesthesia Advertise in A&A Career Center Most Read Special Article: 2010 Anesthesia & Analgesia Guide for Authors: 2009-2010 Editorial Board, Anesthesia & Analgesia Hand Contamination of Anesthesia Providers Is an Important Risk Factor for Intraoperative Bacterial Transmission Review Article: The Role of the Perioperative Period in Recurrence After Cancer Surgery Postoperative Sore Throat: More Answers Than Questions Electrical Safety in the Operating Room: Dry Versus Wet ? View all Most Read articles Cited The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials ASE/SCA Guidelines for Performing a Comprehensive Intraoperative Multiplane Transesophageal Echocardiography Examination: Recommendations of the American Society of Echocardiography Council for Intraoperative Echocardiography and the Society of Cardiovascular Anesthesiologists Task Force for Certification in Perioperative Transesophageal Echocardiography Consensus Guidelines for Managing Postoperative Nausea and Vomiting Cerebral Autoregulation and Flow/Metabolism Coupling during Cardiopulmonary Bypass: The Influence of Paco2 A Postanesthetic Recovery Score ? View all Most Cited articles Copyright ? 2011 by the International Anesthesia Research Society

Print ISSN: 0003-2999 Online ISSN: 1526-7598

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