Cardiac intervention using high‐intensity focused ultrasound: creation of interatrial communication in beating heart of an anesthetized rabbit

Cardiac intervention using high?intensity focused ultrasound: creation of interatrial communication in beating heart of an anesthetized rabbit - Fujisaki - 2010 - Ultrasound in Obstetrics and Gynecology - Wiley Online LibrarySkip to Main Content

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Cardiac intervention using high?intensity focused ultrasound: creation of interatrial communication in beating heart of an anesthetized rabbitM. Fujisaki1,*, T. Chiba3, S. Enosawa4, T. Dohi2, S. Takamoto1Article first published online: 27 OCT 2010

DOI: 10.1002/uog.8830

Copyright ? 2010 ISUOG. Published by John Wiley & Sons, Ltd.

Issue

Ultrasound in Obstetrics and GynecologyVolume 36, Issue 5, pages 607–612, November 2010

Additional Information

How to CiteFujisaki, M., Chiba, T., Enosawa, S., Dohi, T. and Takamoto, S. (2010), Cardiac intervention using high?intensity focused ultrasound: creation of interatrial communication in beating heart of an anesthetized rabbit. Ultrasound in Obstetrics and Gynecology, 36: 607–612. doi: 10.1002/uog.8830

Author Information1

Department of Cardiothoracic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

2

Department of Mechano?informatics, Graduate School of Information Science and Technology, University of Tokyo, Tokyo, Japan

3

Department of Strategic Medicine, National Center for Child Health and Development, Tokyo, Japan

4

Department of Regenerative Medicine Systems Biomedicine Unit, National Research Institute for Child Health and Development, Tokyo, Japan

Email: M. Fujisaki (masafujicardio@yahoo.co.jp)

*Correspondence: M. Fujisaki, Cardiothoracic Surgery, Graduate School of Medicine, University of Tokyo, 7?3?1 Hongo Bunkyo?Ku Tokyo, Tokyo 1138655, Japan

Publication HistoryIssue published online: 27 OCT 2010Article first published online: 27 OCT 2010Accepted manuscript online: 14 SEP 2010 09:54AM ESTManuscript Accepted: 16 DEC 2009 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (400K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Get PDF (400K) Keywords:balloon atrioseptostomy;BAS;cardiac intervention;computer?assisted;HIFU;high?intensity focused ultrasound;highly restrictive atrial septumAbstractObjective

Current fetal cardiac intervention for restrictive atrial septum is invasive and technically demanding. We investigated the feasibility of computer?assisted high?intensity focused ultrasound (HIFU) for cardiac intervention on the atrial septum of a beating heart.

Methods

To create an interatrial communication in the beating heart of nine anesthetized rabbits, the heart was exposed surgically and placed under a water?filled tank, in contact with the tank's membranous base. A HIFU transducer (3.3 MHz) coupled with a diagnostic ultrasound probe (10.0 MHz) was placed in the tank over the beating heart. The focus of the HIFU transducer was set so that it could create a hole in the target area on the atrial septum during the early diastolic phase. HIFU delivery was controlled based on ultrasound images captured with real?time image?recognition software. We attempted to create interatrial communication using HIFU and assessed the cardiac tissue specimen pathologically.

Results

In eight of nine rabbits, small holes in the atrial septum were successfully created. Serious complications occurred in two animals: a fatal atrioventricular block in one and a cardiac tamponade in the other.

Conclusion

HIFU combined with a computer?assisted imaging system might be useful to create interatrial communication in beating hearts. This procedure may be helpful for making current fetal cardiac intervention less invasive. Copyright ? 2010 ISUOG. Published by John Wiley & Sons, Ltd.

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